DENND2B

Across TCGA patient cohorts, DENND2B mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DENND2B-associated genes across cancer lineages are Caspase-7-cleavedD198, MSH2, and MEK1. Each is linked with DENND2B in more than 3 cancer types. Because this analysis shows association rather than direction, both DENND2B-to-partner and partner-to-DENND2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by DENND2B-low versus DENND2B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND2B→partner) and Y-score (partner→DENND2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.712	+3.338	<.001	.004	3	4
CESC	MSH2 →	-0.342	-3.000	.001	.033	3	3
UCEC	MEK1 →	+0.334	+1.807	.002	.003	3	3
COAD	Shc_pY317 →	-0.211	-3.157	.003	.018	3	3
UCEC	ATM →	-0.415	-2.087	.002	.005	3	3
COAD	eEF2 →	+0.299	+2.467	.019	.011	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

Caspase-7-cleavedD198 by DENND2B expression — COAD

Explore this box plot interactively →