DENND2B

Across TCGA cell cohorts, DENND2B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,808 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible DENND2B-associated GO terms across cancer lineages are Negative regulation of myoblast fusion, Negative regulation of syncytium formation by plasma membrane fusion, and Process utilizing autophagic mechanism. Each is linked with DENND2B in more than 11 cancer types. Because this analysis shows association rather than direction, both DENND2B-to-partner and partner-to-DENND2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of myoblast fusion grouped by DENND2B-low versus DENND2B-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND2B→partner) and Y-score (partner→DENND2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of myoblast fusion →	+0.108	+1.662	<.001	<.001	3	12
STOMACH	Negative regulation of syncytium formation by plasma membrane fusion →	+0.108	+1.662	<.001	<.001	3	12
BLOOD_Lymphoma	Process utilizing autophagic mechanism →	+0.041	+1.101	<.001	<.001	3	12
BLOOD_Lymphoma	Autophagy →	+0.041	+1.101	<.001	<.001	3	12
OESOPHAGUS	Regulation of stress-activated protein kinase signaling cascade →	+0.089	+1.196	<.001	.002	3	11
BREAST	Positive regulation of protein localization to nucleus →	+0.065	+1.704	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,808 associations by consensus.

Negative regulation of myoblast fusion by DENND2B expression — STOMACH

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