DENND2B

Across TCGA cell cohorts, DENND2B mutation is significantly associated with the RNA expression of many other genes, with 326 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DENND2B-associated genes across cancer lineages are OR1G1, PRR30, and IQCF1. Each is linked with DENND2B in more than 1 cancer types. Because this analysis shows association rather than direction, both DENND2B-to-partner and partner-to-DENND2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1G1 grouped by DENND2B-low versus DENND2B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND2B→partner) and Y-score (partner→DENND2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR1G1 →	+0.061	+4.121	<.001	<.001	3	2
BLOOD_Leukemia	PRR30 →	+0.015	+3.684	<.001	.004	3	2
LARGE_INTESTINE	IQCF1 →	+0.119	+2.121	.008	.005	3	2
BLOOD_Leukemia	C9 →	+1.193	+3.544	<.001	.008	3	1
BLOOD_Leukemia	VSX2 →	+0.040	+4.258	<.001	.002	3	1
BLOOD_Leukemia	CST8 →	+0.031	+3.969	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 326 associations by consensus.

OR1G1 by DENND2B expression — BLOOD_Leukemia

Explore this box plot interactively →