Across TCGA pan-cancer cohorts, DENND1C mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of DENND1C’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where DENND1C mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types DENND1C is over-expressed in tumor, although a few such as LUAD and LSCC show the opposite, repressed pattern.

LUAD, CCRCC, and LSCC are the cancer types where DENND1C tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DENND1C mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	II,III,IV	−0.183	.001	5	view →
CCRCC	All	All	+0.822	<.001	4	view →
LSCC	Male	All	−0.203	<.001	4	view →
PDAC	Male	III,IV	−0.678	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: DENND1C RNA expression & survival · all DENND1C data types