Across TCGA pan-cancer cohorts, DENND1C RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated DENND1C data layer compared with 6 for mutation status and 3 for mass-spec protein.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DENND1C RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated DENND1C expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.
HNSC, SKCM, and ACC are the cancer types where DENND1C RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.