Across TCGA patient cohorts, DENND1C RNA expression is significantly associated with the protein abundance of many other proteins, with 16,610 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DENND1C-associated proteins across cancer lineages are STXBP2, PLOD2, and ARHGAP25_S488. Each is linked with DENND1C in more than 5 cancer types. Because this analysis shows association rather than direction, both DENND1C-to-partner and partner-to-DENND1C results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND1C→partner) and Y-score (partner→DENND1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	STXBP2 →	+0.680	+0.826	<.001	<.001	3	6
CCRCC	PLOD2 →	-0.942	-0.564	<.001	<.001	3	6
HNSC	ARHGAP25_S488 →	+0.645	+0.448	<.001	<.001	3	5
GBM	RPS6KA3 →	+0.336	+0.678	<.001	<.001	3	5
GBM	CD3E →	+1.261	+1.038	.001	<.001	3	5
GBM	CD4 →	+0.833	+0.829	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,610 associations by consensus.

Exploration

DENND1C survival (RNA) · tumor vs normal (RNA) · all DENND1C data types