Across TCGA patient cohorts, DENND1C protein abundance is significantly associated with the RNA expression of many other genes, with 17,338 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DENND1C-associated genes across cancer lineages are NLRC4, CYTH4, and NCF4. Each is linked with DENND1C in more than 6 cancer types. Because this analysis shows association rather than direction, both DENND1C-to-partner and partner-to-DENND1C results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND1C→partner) and Y-score (partner→DENND1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NLRC4 →	+0.729	+0.551	<.001	<.001	3	7
GBM	CYTH4 →	+1.065	+0.622	<.001	<.001	3	7
GBM	NCF4 →	+1.145	+0.601	<.001	<.001	3	7
BRCA	IL2RB →	+1.381	+0.452	<.001	<.001	3	7
BRCA	GZMB →	+1.734	+0.461	<.001	<.001	3	7
BRCA	SLA2 →	+1.042	+0.431	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,338 associations by consensus.

Exploration

DENND1C survival (RNA) · tumor vs normal (RNA) · all DENND1C data types