Across TCGA patient cohorts, DENND1C mutation is significantly associated with the RNA expression of many other genes, with 1,698 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DENND1C-associated genes across cancer lineages are MIR6766, SLC25A33, and SNRPBP1. Each is linked with DENND1C in more than 2 cancer types. Because this analysis shows association rather than direction, both DENND1C-to-partner and partner-to-DENND1C results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND1C→partner) and Y-score (partner→DENND1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6766 →	+0.161	+2.095	.003	.007	3	3
UCEC	SLC25A33 →	+0.456	+2.095	.001	.003	3	3
LUAD	SNRPBP1 →	+0.196	+3.690	<.001	.009	3	3
UCEC	MFN2 →	+0.354	+2.158	.007	.009	3	3
SKCM	GGTLC3 →	+0.041	+1.899	<.001	.001	3	3
SKCM	PRADC1 →	+0.467	+2.220	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,698 associations by consensus.

Exploration

DENND1C survival (RNA) · tumor vs normal (RNA) · all DENND1C data types