Across TCGA patient cohorts, DENND1C mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DENND1C-associated genes across cancer lineages are p62 Lck ligand, 14-3-3_beta, and JNK2. Each is linked with DENND1C in more than 2 cancer types. Because this analysis shows association rather than direction, both DENND1C-to-partner and partner-to-DENND1C results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND1C→partner) and Y-score (partner→DENND1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.424	+3.807	<.001	<.001	3	3
UCEC	14-3-3_beta →	-0.077	-2.973	.041	.035	3	2
SKCM	JNK2 →	+0.211	+2.017	.008	.005	3	2
UCEC	ATM →	-0.448	-1.415	.008	.046	3	2
UCEC	Caspase-8 →	-0.209	-2.780	.026	.003	3	2
UCEC	Cyclin-B1 →	+0.576	+2.169	.006	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

DENND1C survival (RNA) · tumor vs normal (RNA) · all DENND1C data types