Across TCGA cell cohorts, DENND1C RNA expression is significantly associated with the go_rna of many other GO terms, with 5,146 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible DENND1C-associated GO terms across cancer lineages are Cellular response to alcohol, Serotonin secretion, and Serotonin production involved in inflammatory response. Each is linked with DENND1C in more than 12 cancer types. Because this analysis shows association rather than direction, both DENND1C-to-partner and partner-to-DENND1C results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND1C→partner) and Y-score (partner→DENND1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Cellular response to alcohol →	+0.079	+1.807	.002	<.001	3	13
STOMACH	Serotonin secretion →	+1.655	+2.659	<.001	<.001	3	13
STOMACH	Serotonin production involved in inflammatory response →	+1.655	+2.659	<.001	<.001	3	13
STOMACH	Serotonin secretion involved in inflammatory response →	+1.655	+2.659	<.001	<.001	3	13
PANCREAS	Bundle of His cell to Purkinje myocyte communication →	+0.295	+2.899	<.001	<.001	3	13
BREAST	Negative regulation of Arp2/3 complex-mediated actin nucleation →	+0.199	+2.470	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,146 associations by consensus.

Exploration

DENND1C survival (RNA) · tumor vs normal (RNA) · all DENND1C data types