Across TCGA cell cohorts, DENND1C mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible DENND1C-associated genes across cancer lineages are ODF1, MS4A14, and OR6K3. Each is linked with DENND1C in more than 1 cancer types. Because this analysis shows association rather than direction, both DENND1C-to-partner and partner-to-DENND1C results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND1C→partner) and Y-score (partner→DENND1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ODF1 →	+0.996	+4.906	<.001	.006	3	1
OESOPHAGUS	MS4A14 →	+0.053	+4.906	<.001	.006	3	1
OESOPHAGUS	OR6K3 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	SPINK8 →	+0.263	+4.906	<.001	.006	3	1
OESOPHAGUS	C2orf83 →	+0.020	+4.906	<.001	.006	3	1
LARGE_INTESTINE	COMP →	+0.400	+3.459	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

DENND1C survival (RNA) · tumor vs normal (RNA) · all DENND1C data types