Across TCGA cell cohorts, DENND1C mutation is significantly associated with the mutation status of many other genes, with 3,546 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DENND1C-associated genes across cancer lineages are PATJ, TRPC4, and SETD1A. Each is linked with DENND1C in more than 3 cancer types. Because this analysis shows association rather than direction, both DENND1C-to-partner and partner-to-DENND1C results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND1C→partner) and Y-score (partner→DENND1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PATJ →	+4.415	+4.977	.007	.007	1	4
OVARY	TRPC4 →	+4.415	+4.977	.007	.007	1	4
STOMACH	SETD1A →	+3.357	+4.285	.005	.005	1	4
LUNG_NSCLC_LUAD	SLFN13 →	+5.772	+5.772	.002	.002	1	4
BLOOD_Leukemia	LTBP3 →	+3.285	+4.209	<.001	<.001	1	4
LARGE_INTESTINE	MYOF →	+1.584	+2.769	.008	.008	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,546 associations by consensus.

Exploration

DENND1C survival (RNA) · tumor vs normal (RNA) · all DENND1C data types