DENND1A

Across TCGA pan-cancer cohorts, DENND1A Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DENND1A data layer compared with 24 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher DENND1A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DENND1A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRC, COAD, and PRAD are the cancer types where DENND1A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.244	0.810	.008	12	view →
COAD	OS	Median	III,IV	0.159	0.692	.021	9	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	OS	Median	All	0.966	0.658	.033	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DENND1A–KIRC (OS)

Open the KIRC breakdown →