DENND1A

Across TCGA pan-cancer cohorts, DENND1A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DENND1A data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DENND1A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DENND1A expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

CCRCC, GBM, and PDAC are the cancer types where DENND1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.846	0.504	.002	58	view →
GBM	OS	Median	All	0.542	0.271	.003	8	view →
PDAC	OS	Quartile	All	0.822	0.910	.032	7	view →
HNSC	OS	Tertile	III,IV	0.504	0.854	.006	7	view →
LUAD	OS	Tertile	All	0.736	0.957	.034	4	view →
LSCC	DFS	Quartile	All	1.000	0.289	.013	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DENND1A–CCRCC (DFS)

Open the CCRCC breakdown →