DENND1A

Across TCGA patient cohorts, DENND1A protein abundance is significantly associated with the RNA expression of many other genes, with 11,599 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DENND1A-associated genes across cancer lineages are SIGLEC8, LCP2, and PPP1R16B. Each is linked with DENND1A in more than 4 cancer types. Because this analysis shows association rather than direction, both DENND1A-to-partner and partner-to-DENND1A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DENND1A versus SIGLEC8 in GBM, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND1A→partner) and Y-score (partner→DENND1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SIGLEC8 →	+1.060	+0.139	.001	.002	3	5
LUAD	LCP2 →	+0.775	+0.253	<.001	<.001	3	5
GBM	PPP1R16B →	+1.410	+0.201	<.001	<.001	3	5
GBM	CD22 →	+1.023	+0.129	<.001	.001	3	5
BRCA	PREX1 →	+1.038	+0.222	.001	<.001	3	5
LSCC	FAM78A →	+0.580	+0.184	.002	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,599 associations by consensus.

DENND1A vs SIGLEC8 — GBM

Explore this scatter interactively →