DENND1A

Across TCGA patient cohorts, DENND1A mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DENND1A-associated genes across cancer lineages are MSH2, Rab25, and ATM. Each is linked with DENND1A in more than 2 cancer types. Because this analysis shows association rather than direction, both DENND1A-to-partner and partner-to-DENND1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by DENND1A-low versus DENND1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND1A→partner) and Y-score (partner→DENND1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.183	-3.433	.025	.005	3	3
UCEC	Rab25 →	-0.338	-1.662	.003	.011	3	3
UCEC	ATM →	-0.690	-2.392	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.541	+1.604	.009	.021	3	3
SKCM	CDK1 →	+0.172	+2.502	.011	.001	3	3
UCEC	eIF4E →	+0.150	+1.662	.044	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

MSH2 by DENND1A expression — UCEC

Explore this box plot interactively →