DENND10

Across TCGA pan-cancer cohorts, DENND10 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DENND10 data layer compared with 23 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher DENND10 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DENND10 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

BLCA, KICH, and LIHC are the cancer types where DENND10 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.082	0.688	<.001	24	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
LIHC	DFS	Median	All	0.082	0.544	<.001	12	view →
UCEC	DFS	Median	All	1.000	0.632	.037	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DENND10–BLCA (OS)

Open the BLCA breakdown →