DENND10

Across TCGA pan-cancer cohorts, DENND10 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of DENND10’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where DENND10 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DENND10 is over-expressed in tumor, although a few such as COAD and KIRC show the opposite, repressed pattern.

LIHC, LUAD, and COAD are the cancer types where DENND10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DENND10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Male	All	+1.033	<.001	9	view →
LUAD	Male	II,III,IV	+0.838	<.001	7	view →
COAD	Female	All	−0.532	<.001	6	view →
KIRC	Male	II,III,IV	−0.464	<.001	6	view →
KICH	All	All	−0.686	<.001	5	view →
LUSC	All	II,III,IV	+0.436	<.001	4	view →
HNSC	All	IV	+0.358	.011	4	view →
BLCA	Male	III,IV	+0.494	.006	3	view →
THCA	All	All	−0.205	.002	3	view →
STAD	All	All	+0.336	.024	2	view →
ESCA	All	All	+0.628	.030	1	view →
CHOL	All	All	+0.412	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

DENND10–LIHC

Open the LIHC breakdown →