DENND10

Across TCGA pan-cancer cohorts, DENND10 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DENND10 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DENND10 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated DENND10 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, PDAC, and UCEC are the cancer types where DENND10 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.950	0.763	<.001	49	view →
PDAC	OS	Tertile	III,IV	1.000	0.328	.006	27	view →
UCEC	DFS	Tertile	All	1.000	0.817	.003	12	view →
CCRCC	DFS	Median	All	0.976	0.851	.005	8	view →
LUAD	DFS	Quartile	All	0.822	0.317	.013	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DENND10–HNSC (OS)

Open the HNSC breakdown →