DENND10

Across TCGA patient cohorts, DENND10 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,715 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DENND10-associated proteins across cancer lineages are CACUL1, KIFBP, and GLRX3. Each is linked with DENND10 in more than 4 cancer types. Because this analysis shows association rather than direction, both DENND10-to-partner and partner-to-DENND10 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DENND10 versus CACUL1 in OV, with a Pearson correlation of 0.41.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND10→partner) and Y-score (partner→DENND10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CACUL1 →	+0.323	+0.541	<.001	<.001	3	5
UCEC	KIFBP →	+0.288	+0.484	<.001	<.001	3	5
LSCC	GLRX3 →	+0.320	+0.446	<.001	<.001	3	5
PDAC	TIAL1 →	+0.220	+0.308	<.001	.001	3	5
OV	NHLRC2 →	+0.236	+0.468	.005	.002	3	5
LSCC	MMS19 →	+0.190	+0.333	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,715 associations by consensus.

DENND10 vs CACUL1 — OV

Explore this scatter interactively →