DENND10

Across TCGA patient cohorts, DENND10 protein abundance is significantly associated with the RNA expression of many other genes, with 10,329 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DENND10-associated genes across cancer lineages are DSCC1, TTK, and KIF18A. Each is linked with DENND10 in more than 5 cancer types. Because this analysis shows association rather than direction, both DENND10-to-partner and partner-to-DENND10 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DENND10 versus DSCC1 in HNSC, with a Pearson correlation of -0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND10→partner) and Y-score (partner→DENND10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DSCC1 →	-0.975	-0.182	<.001	<.001	3	6
GBM	TTK →	-1.137	-0.279	<.001	<.001	3	5
GBM	KIF18A →	-0.928	-0.269	.001	<.001	3	5
GBM	TICRR →	-0.723	-0.224	.001	.004	3	5
HNSC	KNTC1 →	-0.978	-0.195	<.001	<.001	3	5
HNSC	PRC1-AS1 →	-0.505	-0.162	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,329 associations by consensus.

DENND10 vs DSCC1 — HNSC

Explore this scatter interactively →