DENND10

Across TCGA patient cohorts, DENND10 mutation is significantly associated with the RNA expression of many other genes, with 3,122 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DENND10-associated genes across cancer lineages are SNX18P24, RARRES2P7, and RNA5SP447. Each is linked with DENND10 in more than 1 cancer types. Because this analysis shows association rather than direction, both DENND10-to-partner and partner-to-DENND10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNX18P24 grouped by DENND10-low versus DENND10-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND10→partner) and Y-score (partner→DENND10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	SNX18P24 →	+0.212	+5.812	<.001	.003	3	2
BLCA	RARRES2P7 →	+0.100	+4.314	<.001	.009	3	2
CESC	RNA5SP447 →	+0.349	+5.201	.004	.007	3	2
CESC	RBPJP6 →	+0.039	+7.164	<.001	<.001	3	2
UCEC	RNU6-5P →	+0.433	+2.587	.005	<.001	3	2
UCEC	PSAT1P4 →	+0.205	+2.701	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,122 associations by consensus.

SNX18P24 by DENND10 expression — CESC

Explore this box plot interactively →