DENND10

Across TCGA patient cohorts, DENND10 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DENND10-associated genes across cancer lineages are JNK2, MEK1, and Notch1. Each is linked with DENND10 in more than 1 cancer types. Because this analysis shows association rather than direction, both DENND10-to-partner and partner-to-DENND10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by DENND10-low versus DENND10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND10→partner) and Y-score (partner→DENND10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.322	+3.179	<.001	.010	3	1
UCEC	MEK1 →	+0.511	+3.584	.003	.002	3	1
UCEC	Notch1 →	+0.190	+3.009	.005	.019	3	1
UCEC	PDCD4 →	-0.890	-3.584	<.001	.002	3	1
UCEC	Annexin-1 →	+0.511	+2.827	.044	.035	3	1
UCEC	Shc_pY317 →	-0.170	-2.459	.020	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

JNK2 by DENND10 expression — UCEC

Explore this box plot interactively →