DENND10

Across TCGA cell cohorts, DENND10 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,060 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DENND10-associated GO terms across cancer lineages are Phosphatidylinositol metabolic process, Phosphatidylinositol biosynthetic process, and Viral translational termination-reinitiation. Each is linked with DENND10 in more than 10 cancer types. Because this analysis shows association rather than direction, both DENND10-to-partner and partner-to-DENND10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Phosphatidylinositol metabolic process grouped by DENND10-low versus DENND10-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND10→partner) and Y-score (partner→DENND10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Phosphatidylinositol metabolic process →	+0.050	+0.719	<.001	.003	3	11
BREAST	Phosphatidylinositol biosynthetic process →	+0.050	+0.681	.004	.003	3	10
BREAST	Viral translational termination-reinitiation →	+0.086	+0.714	.001	<.001	3	10
BREAST	Post-Golgi vesicle-mediated transport →	+0.100	+0.773	<.001	<.001	3	10
OVARY	Regulation of smoothened signaling pathway →	+0.061	+0.765	<.001	<.001	3	10
LUNG_NSCLC_LUAD	Melanosome assembly →	+0.096	+0.953	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,060 associations by consensus.

Phosphatidylinositol metabolic process by DENND10 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →