DENND10

Across TCGA cell cohorts, DENND10 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DENND10-associated genes across cancer lineages are IFNA4, BRDT, and MAGEB1. Each is linked with DENND10 in more than 1 cancer types. Because this analysis shows association rather than direction, both DENND10-to-partner and partner-to-DENND10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNA4 grouped by DENND10-low versus DENND10-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND10→partner) and Y-score (partner→DENND10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IFNA4 →	+0.058	+4.922	<.001	.009	3	1
LARGE_INTESTINE	BRDT →	+0.117	+3.333	<.001	.009	3	1
LARGE_INTESTINE	MAGEB1 →	+0.159	+2.878	.002	.009	3	1
LARGE_INTESTINE	IQCF5 →	+0.021	+3.700	<.001	.009	3	1
LARGE_INTESTINE	USP17L7 →	+0.057	+3.333	<.001	.009	3	1
LARGE_INTESTINE	CD300H →	+0.031	+4.000	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

IFNA4 by DENND10 expression — BLOOD_Leukemia

Explore this box plot interactively →