DEGS1

Across TCGA patient cohorts, DEGS1 protein abundance is significantly associated with the RNA expression of many other genes, with 9,371 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DEGS1-associated genes across cancer lineages are CTC1, GTPBP10, and MADD. Each is linked with DEGS1 in more than 4 cancer types. Because this analysis shows association rather than direction, both DEGS1-to-partner and partner-to-DEGS1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DEGS1 versus CTC1 in BRCA, with a Pearson correlation of -0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEGS1→partner) and Y-score (partner→DEGS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CTC1 →	-0.516	-0.294	<.001	.001	3	5
HNSC	GTPBP10 →	-0.614	-0.313	<.001	<.001	3	4
UCEC	MADD →	-0.542	-0.732	<.001	<.001	3	4
BRCA	FAM117A →	-0.508	-0.378	.001	<.001	3	4
HNSC	MTERF4 →	-0.387	-0.259	<.001	.002	3	4
BRCA	VPS36 →	-0.413	-0.304	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,371 associations by consensus.

DEGS1 vs CTC1 — BRCA

Explore this scatter interactively →