DEGS1

Across TCGA cell cohorts, DEGS1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DEGS1-associated genes across cancer lineages are DEFA4, TBC1D21, and GP9. Each is linked with DEGS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEGS1-to-partner and partner-to-DEGS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA4 grouped by DEGS1-low versus DEGS1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEGS1→partner) and Y-score (partner→DEGS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEFA4 →	+0.026	+4.022	<.001	.006	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	GP9 →	+0.081	+3.196	.001	.007	3	1
LARGE_INTESTINE	OR51D1 →	+0.007	+3.632	<.001	.003	3	1
LARGE_INTESTINE	KRTAP10-2 →	+0.057	+3.994	<.001	.002	3	1
BLOOD_Leukemia	OR11H1 →	+0.103	+5.786	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

DEFA4 by DEGS1 expression — LARGE_INTESTINE

Explore this box plot interactively →