Across TCGA patient cohorts, DEFB136 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. COAD shows the largest number of these associations.

The most reproducible DEFB136-associated genes across cancer lineages are RNU6-1175P, RNU6ATAC30P, and RNU6-1068P. Each is linked with DEFB136 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB136-to-partner and partner-to-DEFB136 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB136→partner) and Y-score (partner→DEFB136) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-1175P →	+0.373	+4.693	.003	.007	3	1
COAD	RNU6ATAC30P →	+0.384	+4.893	.002	.005	3	1
COAD	RNU6-1068P →	+0.361	+4.602	<.001	.008	3	1
COAD	DCANP1 →	+0.021	+4.790	<.001	.006	3	1
COAD	RNU4ATAC15P →	+0.332	+5.251	<.001	.003	3	1
COAD	IGHVIII-67-4 →	+0.152	+4.790	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

DEFB136 survival (RNA) · tumor vs normal (RNA) · all DEFB136 data types