Across TCGA patient cohorts, DEFB135 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DEFB135-associated genes across cancer lineages are TBL1Y, MIR4418, and SPCS2P2. Each is linked with DEFB135 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB135-to-partner and partner-to-DEFB135 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB135→partner) and Y-score (partner→DEFB135) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TBL1Y →	+0.159	+5.420	<.001	.005	3	1
COAD	MIR4418 →	+1.243	+5.893	<.001	.002	3	1
COAD	SPCS2P2 →	+0.195	+5.435	<.001	.005	3	1
UCEC	RBM17P2 →	+0.068	+6.027	<.001	.002	3	1
UCEC	MIR5003 →	+0.636	+5.133	<.001	.008	3	1
UCEC	RNU6-147P →	+0.619	+5.551	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

DEFB135 survival (RNA) · tumor vs normal (RNA) · all DEFB135 data types