Across TCGA cell cohorts, DEFB135 RNA expression is significantly associated with the mutation status of many other genes, with 8 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible DEFB135-associated genes across cancer lineages are INA, PABPC5, and NRG3. Each is linked with DEFB135 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB135-to-partner and partner-to-DEFB135 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB135→partner) and Y-score (partner→DEFB135) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	INA →	+5.285	+0.356	.003	<.001	3	1
STOMACH	PABPC5 →	+4.285	+0.267	.007	<.001	3	1
STOMACH	NRG3 →	+5.285	+0.356	.003	<.001	3	1
SKIN	FAM83B →	+2.830	+0.215	.004	<.001	3	1
SKIN	CST1 →	+5.415	+0.640	.004	<.001	3	1
SKIN	PRAMEF1 →	+5.000	+0.518	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

DEFB135 survival (RNA) · tumor vs normal (RNA) · all DEFB135 data types