Across TCGA patient cohorts, DEFB134 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DEFB134-associated genes across cancer lineages are MLECP1, BPTFP1, and RNU6-13P. Each is linked with DEFB134 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB134-to-partner and partner-to-DEFB134 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB134→partner) and Y-score (partner→DEFB134) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MLECP1 →	+0.113	+5.226	.003	.003	3	1
UCEC	BPTFP1 →	+0.113	+4.621	.003	.008	3	1
UCEC	RNU6-13P →	+0.663	+4.969	<.001	.002	3	1
UCEC	MIR100 →	+0.539	+6.245	<.001	<.001	3	1
UCEC	RFKP1 →	+0.224	+5.827	<.001	<.001	3	1
UCEC	MIR1285-2 →	+0.729	+5.223	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

DEFB134 survival (RNA) · tumor vs normal (RNA) · all DEFB134 data types