Across TCGA pan-cancer cohorts, DEFB134 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated DEFB134 data layer compared with 1 for mutation status.
The strongest signal is observed in uveal melanoma (UVM), where higher DEFB134 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DEFB134 expression acts as an unfavorable survival marker, although some lineages such as THCA and LGG show a favorable association.
UVM, COAD, and THCA are the cancer types where DEFB134 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.