Across TCGA cell cohorts, DEFB133 RNA expression is significantly associated with the mutation status of many other genes, with 138 significant associations in total. CNS shows the largest number of these associations.

The most reproducible DEFB133-associated genes across cancer lineages are KIF21A, C8orf34, and MAP3K12. Each is linked with DEFB133 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB133-to-partner and partner-to-DEFB133 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB133→partner) and Y-score (partner→DEFB133) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	KIF21A →	+4.035	+0.020	.006	<.001	3	2
BLOOD_Lymphoma	C8orf34 →	+4.247	+0.023	.004	<.001	3	2
LUNG_NSCLC_LUAD	MAP3K12 →	+5.228	+0.084	.005	.003	3	2
LUNG_NSCLC_LUAD	ERLIN2 →	+5.228	+0.194	.005	<.001	3	2
LUNG_NSCLC_LUAD	GLOD4 →	+5.228	+0.194	.005	<.001	3	2
LUNG_NSCLC_LUAD	EXOC1 →	+5.813	+0.164	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 138 associations by consensus.

Exploration

DEFB133 survival (RNA) · tumor vs normal (RNA) · all DEFB133 data types