Across TCGA patient cohorts, DEFB131A mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DEFB131A-associated genes across cancer lineages are MIR6882, OR6C64P, and TAS2R39. Each is linked with DEFB131A in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB131A-to-partner and partner-to-DEFB131A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB131A→partner) and Y-score (partner→DEFB131A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR6882 →	+0.429	+4.680	<.001	.007	3	1
SKCM	OR6C64P →	+0.049	+4.594	<.001	.008	3	1
SKCM	TAS2R39 →	+0.091	+4.500	<.001	.005	3	1
UCEC	MIR4646 →	+1.089	+5.943	<.001	<.001	3	1
SKCM	RNU6-1149P →	+0.551	+4.440	<.001	.006	3	1
SKCM	RN7SL74P →	+0.108	+4.867	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

DEFB131A survival (RNA) · tumor vs normal (RNA) · all DEFB131A data types