DEFB129

Across TCGA patient cohorts, DEFB129 mutation is significantly associated with the RNA expression of many other genes, with 227 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DEFB129-associated genes across cancer lineages are RNU6-715P, UBE2V1P10, and RNU6-663P. Each is linked with DEFB129 in more than 2 cancer types. Because this analysis shows association rather than direction, both DEFB129-to-partner and partner-to-DEFB129 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-715P grouped by DEFB129-low versus DEFB129-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB129→partner) and Y-score (partner→DEFB129) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-715P →	+0.263	+7.930	<.001	.008	3	3
BLCA	UBE2V1P10 →	+0.169	+7.640	<.001	.009	3	2
LUSC	RNU6-663P →	+0.259	+6.333	<.001	<.001	3	2
BLCA	SNORD115-22 →	+0.448	+7.640	<.001	.009	3	2
LUAD	RNU6-1286P →	+0.438	+7.930	<.001	.008	3	1
LUAD	MIR105-2 →	+0.441	+7.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 227 associations by consensus.

RNU6-715P by DEFB129 expression — LUAD

Explore this box plot interactively →