Across TCGA patient cohorts, DEFB128 mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DEFB128-associated genes across cancer lineages are IL17A, IL21, and RNU7-133P. Each is linked with DEFB128 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB128-to-partner and partner-to-DEFB128 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB128→partner) and Y-score (partner→DEFB128) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IL17A →	+0.367	+4.516	<.001	<.001	3	1
UCEC	IL21 →	+0.259	+2.763	<.001	.009	3	1
SKCM	RNU7-133P →	+0.612	+5.436	<.001	.005	3	1
UCEC	LILRP1 →	+0.121	+3.981	.006	.002	3	1
UCEC	IGKV7-3 →	+0.843	+3.746	.008	.004	3	1
UCEC	IGLV3-12 →	+1.510	+3.461	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Exploration

DEFB128 survival (RNA) · tumor vs normal (RNA) · all DEFB128 data types