DEFB127

Across TCGA patient cohorts, DEFB127 protein abundance is significantly associated with the RNA expression of many other genes, with 3,931 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible DEFB127-associated genes across cancer lineages are PTK6, CRYBG2, and KRT6A. Each is linked with DEFB127 in more than 3 cancer types. Because this analysis shows association rather than direction, both DEFB127-to-partner and partner-to-DEFB127 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DEFB127 versus PTK6 in UCEC, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB127→partner) and Y-score (partner→DEFB127) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PTK6 →	+1.250	+0.583	.002	.008	3	3
HNSC	CRYBG2 →	+1.840	+1.536	<.001	.007	3	3
HNSC	KRT6A →	+2.926	+2.117	.001	<.001	3	3
OV	RAB2A →	+0.599	+0.858	<.001	<.001	3	2
PDAC	CLINT1 →	+0.601	+0.988	.003	.009	3	2
PDAC	DGUOK →	+0.351	+0.998	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,931 associations by consensus.

DEFB127 vs PTK6 — UCEC

Explore this scatter interactively →