DEFB127

Across TCGA pan-cancer cohorts, DEFB127 RNA is linked to patient survival in 4 of 34 cancer types, making it the most broadly survival-associated DEFB127 data layer compared with 2 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where higher DEFB127 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DEFB127 expression acts as an unfavorable survival marker.

PAAD, SKCM, and SARC are the cancer types where DEFB127 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PAAD	OS	Tertile	All	0.247	0.618	.003	72	view →
SKCM	OS	Tertile	All	0.690	0.879	.002	57	view →
SARC	OS	Tertile	All	0.065	0.842	<.001	54	view →
KIRP	OS	Tertile	All	0.718	0.908	.014	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DEFB127–PAAD (OS)

Open the PAAD breakdown →