DEFB127

Across TCGA patient cohorts, DEFB127 mutation is significantly associated with the RNA expression of many other genes, with 118 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible DEFB127-associated genes across cancer lineages are MIR8070, MIR1261, and MIR4254. Each is linked with DEFB127 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB127-to-partner and partner-to-DEFB127 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR8070 grouped by DEFB127-low versus DEFB127-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB127→partner) and Y-score (partner→DEFB127) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR8070 →	+0.876	+3.132	<.001	.007	3	2
LUSC	MIR1261 →	+0.313	+4.853	<.001	.004	3	2
LUSC	MIR4254 →	+0.630	+3.919	<.001	.006	3	2
UCEC	MIR579 →	+0.778	+4.279	.001	<.001	3	2
UCEC	MIR1238 →	+0.659	+3.474	<.001	.006	3	2
SKCM	RNU6-1057P →	+0.249	+3.622	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 118 associations by consensus.

MIR8070 by DEFB127 expression — UCEC

Explore this box plot interactively →