DEFB127

Across TCGA cell cohorts, DEFB127 mutation is significantly associated with the mutation status of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DEFB127-associated genes across cancer lineages are CATSPERB, RGPD3, and NLRP14. Each is linked with DEFB127 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB127-to-partner and partner-to-DEFB127 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CATSPERB grouped by DEFB127-low versus DEFB127-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB127→partner) and Y-score (partner→DEFB127) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CATSPERB →	+4.321	+5.285	.005	.005	1	1
BLOOD_Leukemia	RGPD3 →	+4.000	+5.050	.008	.008	1	1
BLOOD_Leukemia	NLRP14 →	+4.736	+5.560	.003	.003	1	1
BLOOD_Leukemia	ASAH2 →	+4.000	+5.050	.008	.008	1	1
BLOOD_Leukemia	HPR →	+4.736	+5.560	.003	.003	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

CATSPERB by DEFB127 expression — BLOOD_Leukemia

Explore this box plot interactively →