DEFB125

Across TCGA patient cohorts, DEFB125 mutation is significantly associated with the RNA expression of many other genes, with 70 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible DEFB125-associated genes across cancer lineages are LINC02283, MTATP6P30, and MIR4666B. Each is linked with DEFB125 in more than 2 cancer types. Because this analysis shows association rather than direction, both DEFB125-to-partner and partner-to-DEFB125 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02283 grouped by DEFB125-low versus DEFB125-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB125→partner) and Y-score (partner→DEFB125) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LINC02283 →	+0.082	+4.469	.006	.006	3	3
LUAD	MTATP6P30 →	+0.064	+7.930	<.001	.008	3	2
SKCM	MIR4666B →	+1.006	+4.255	.007	.001	3	2
BRCA	MIR6853 →	+0.364	+9.057	<.001	.003	3	1
BRCA	OR5M13P →	+0.029	+8.055	.004	.007	3	1
BRCA	SNORD115-47 →	+0.282	+7.731	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

LINC02283 by DEFB125 expression — SKCM

Explore this box plot interactively →