DEFB125

Across TCGA pan-cancer cohorts, DEFB125 RNA is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated DEFB125 data layer compared with 2 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher DEFB125 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DEFB125 expression acts as an unfavorable survival marker, although some lineages such as MESO show a favorable association.

KIRC, KICH, and THCA are the cancer types where DEFB125 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	III,IV	0.226	0.506	.001	66	view →
KICH	OS	Tertile	II,III,IV	0.155	0.880	<.001	27	view →
THCA	DFS	Tertile	II,III,IV	0.802	0.931	.003	18	view →
COAD	OS	Tertile	III,IV	0.435	0.798	.007	18	view →
ACC	DFS	Tertile	All	0.066	0.623	.006	18	view →
MESO	DFS	Tertile	III,IV	0.731	0.257	.029	15	view →
LUAD	OS	Tertile	All	0.608	0.839	.026	9	view →
SARC	OS	Tertile	All	0.592	0.789	.009	9	view →
UVM	OS	Tertile	III,IV	0.220	0.872	.025	9	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

DEFB125–KIRC (DFS)

Open the KIRC breakdown →