DEFB125

Across TCGA cell cohorts, DEFB125 RNA expression is significantly associated with the mutation status of many other genes, with 204 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DEFB125-associated genes across cancer lineages are TMEM131, CCDC158, and USP19. Each is linked with DEFB125 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB125-to-partner and partner-to-DEFB125 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM131 grouped by DEFB125-low versus DEFB125-high in BREAST.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB125→partner) and Y-score (partner→DEFB125) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TMEM131 →	+3.727	+0.024	.002	<.001	3	2
LUNG_SCLC	CCDC158 →	+5.643	+0.086	.002	<.001	3	2
BLOOD_Leukemia	USP19 →	+3.475	+0.025	.006	<.001	3	2
BLOOD_Lymphoma	IGSF10 →	+3.058	+0.010	.002	<.001	3	2
BLOOD_Lymphoma	ARHGAP6 →	+4.058	+0.019	.009	<.001	3	2
SKIN	ZNF665 →	+4.415	+0.025	.007	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 204 associations by consensus.

TMEM131 by DEFB125 expression — BREAST

Explore this box plot interactively →