Across TCGA patient cohorts, DEFB121 mutation is significantly associated with the RNA expression of many other genes, with 47 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible DEFB121-associated genes across cancer lineages are VN1R18P, RNU1-31P, and RNU6-819P. Each is linked with DEFB121 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB121-to-partner and partner-to-DEFB121 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB121→partner) and Y-score (partner→DEFB121) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VN1R18P →	+0.122	+5.133	.006	.008	3	1
LUAD	RNU1-31P →	+0.160	+4.730	<.001	.005	3	1
LUAD	RNU6-819P →	+0.627	+3.926	<.001	.005	3	1
LUAD	RNU6-336P →	+0.238	+4.399	.005	.008	3	1
LUAD	OR52J3 →	+0.024	+4.859	<.001	.004	3	1
LUAD	RNU6-364P →	+0.200	+6.339	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Exploration

DEFB121 survival (RNA) · tumor vs normal (RNA) · all DEFB121 data types