Across TCGA pan-cancer cohorts, DEFB121 RNA is linked to patient survival in 10 of 34 cancer types, making it the most broadly survival-associated DEFB121 data layer compared with 4 for mutation status.
The strongest signal is observed in uterine carcinosarcoma (UCS), where higher DEFB121 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DEFB121 expression acts as an unfavorable survival marker.
UCS, KIRC, and THCA are the cancer types where DEFB121 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.