DEFB119

Across TCGA patient cohorts, DEFB119 mutation is significantly associated with the RNA expression of many other genes, with 2,475 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DEFB119-associated genes across cancer lineages are ADH5, ACACA, and SSRP1. Each is linked with DEFB119 in more than 2 cancer types. Because this analysis shows association rather than direction, both DEFB119-to-partner and partner-to-DEFB119 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADH5 grouped by DEFB119-low versus DEFB119-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB119→partner) and Y-score (partner→DEFB119) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ADH5 →	+0.606	+3.370	.002	.004	3	3
SKCM	ACACA →	+0.376	+1.880	.007	.001	3	2
UCEC	SSRP1 →	+0.602	+3.733	.004	<.001	3	2
UCEC	MTA2 →	+0.495	+2.756	.001	.002	3	2
UCEC	CPSF7 →	+0.426	+2.732	.004	.003	3	2
UCEC	FARP1 →	+0.663	+3.818	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,475 associations by consensus.

ADH5 by DEFB119 expression — UCEC

Explore this box plot interactively →