DEFB119

Across TCGA patient cohorts, DEFB119 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DEFB119-associated genes across cancer lineages are Rb, STAT5a, and Akt_pT308. Each is linked with DEFB119 in more than 2 cancer types. Because this analysis shows association rather than direction, both DEFB119-to-partner and partner-to-DEFB119 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rb grouped by DEFB119-low versus DEFB119-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB119→partner) and Y-score (partner→DEFB119) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Rb →	-0.163	-1.807	.012	.026	3	2
SKCM	STAT5a →	+0.538	+3.017	.017	.017	3	2
UCEC	Akt_pT308 →	+0.787	+2.999	.017	.035	3	2
UCEC	Tuberin_pT1462 →	+0.408	+2.179	<.001	.034	3	2
UCEC	ASNS →	+0.820	+3.321	<.001	.010	3	2
SKCM	NF-kB-p65_pS536 →	+0.422	+3.000	.008	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Rb by DEFB119 expression — SKCM

Explore this box plot interactively →