DEFB118

Across TCGA patient cohorts, DEFB118 mutation is significantly associated with the RNA expression of many other genes, with 181 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible DEFB118-associated genes across cancer lineages are MIR154, NUDT2, and TTYH1. Each is linked with DEFB118 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB118-to-partner and partner-to-DEFB118 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR154 grouped by DEFB118-low versus DEFB118-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB118→partner) and Y-score (partner→DEFB118) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR154 →	+0.388	+7.954	<.001	.008	3	1
SKCM	NUDT2 →	+0.532	+3.641	<.001	.001	3	1
SKCM	TTYH1 →	-1.129	-2.315	.009	.006	3	1
SKCM	FSTL5 →	+1.182	+3.208	.005	.009	3	1
SKCM	MORN4 →	+0.474	+2.341	.009	.003	3	1
SKCM	INSL5 →	+0.102	+1.878	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 181 associations by consensus.

MIR154 by DEFB118 expression — HNSC

Explore this box plot interactively →