DEFB118

Across TCGA pan-cancer cohorts, DEFB118 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of DEFB118’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where DEFB118 RNA is repressed in tumor relative to normal tissue. In most cancer types DEFB118 is over-expressed in tumor, although a few such as BRCA and THCA show the opposite, repressed pattern.

BRCA and THCA are the cancer types where DEFB118 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DEFB118 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	II,III,IV	−0.029	<.001	4	view →
THCA	All	II,III,IV	−0.016	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

DEFB118–BRCA

Open the BRCA breakdown →