DEFB118

Across TCGA cell cohorts, DEFB118 RNA expression is significantly associated with the mutation status of many other genes, with 37 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible DEFB118-associated genes across cancer lineages are KIF5A, LRPPRC, and RSBN1L. Each is linked with DEFB118 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB118-to-partner and partner-to-DEFB118 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIF5A grouped by DEFB118-low versus DEFB118-high in BREAST.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB118→partner) and Y-score (partner→DEFB118) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	KIF5A →	+4.781	+0.032	.003	<.001	3	2
BLOOD_Myeloma	LRPPRC →	+4.807	+0.020	.006	<.001	3	1
BLOOD_Myeloma	RSBN1L →	+4.807	+0.020	.006	<.001	3	1
BREAST	ZNRF4 →	+4.196	+0.026	.006	<.001	3	1
BREAST	ATRNL1 →	+3.781	+0.021	.009	<.001	3	1
BREAST	ARFGEF2 →	+3.781	+0.021	.009	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

KIF5A by DEFB118 expression — BREAST

Explore this box plot interactively →